Senior Research Associate - DMPK
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Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays
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Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)
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Support development and validation of new ADME assays to expand the group’s scientific capabilities
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Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)
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Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators
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Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable
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Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions
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Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams
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Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics
Group Leader - DMPK
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Lead, mentor, and develop a team of scientists engaged in In-Vitro ADME/DMPK studies.
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Oversee the design, execution, analysis, and interpretation of In-Vitro ADME studies, including metabolism, transporter, and drug-drug interaction assessments.
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Manage external CRO partnerships for In-Vivo PK studies, ensuring timely execution, data quality, and delivery.
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Provide scientific guidance and DMPK strategies to support drug discovery and development projects.
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Analyze and interpret study data, prepare technical reports, and present findings to internal and external stakeholders.
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Serve as the primary scientific point of contact for clients, ensuring effective communication and project delivery.
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Support proposal preparation, project scoping, contract review, and project onboarding activities.
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Manage study budgets, resource allocation, and operational efficiency.
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Drive continuous improvement initiatives and implement best practices across DMPK operations.
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Collaborate closely with cross-functional teams to integrate ADME/DMPK data into project decisions.
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Prepare and present monthly MIS reports, including project status, resource utilization, risks, and key performance metrics.
Senior Research Associate - DMPK
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Master's in Lifescience with 4-5 years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.
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Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles
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Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments
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Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding
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Ability to troubleshoot experimental challenges and apply sound scientific judgment
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Self-driven and capable of managing multiple tasks while working within demanding project timelines
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Strong attention to detail and commitment to maintaining high scientific and data quality standards
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Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams
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Strong communication skills for interacting with internal teams, collaborators, and stakeholders
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Highly organised with the ability to function effectively in a fast-paced research environment
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Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs
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A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h
Group Leader - ADME/DMPK
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Ph.D. in Pharmaceutical Sciences, Pharmacology, or a related Life Sciences discipline.
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10–15 years of relevant experience in DMPK, In-Vitro ADME, and Pharmacokinetic sciences within pharmaceutical, biotechnology, or CRO organizations.
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Proven experience in leading scientific teams and managing complex research projects.
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Strong expertise in In-Vitro ADME studies and interpretation of DMPK data.
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Experience managing CRO collaborations and outsourced In-Vivo PK studies.
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Excellent leadership, project management, communication, and stakeholder management skills.
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Strong analytical and problem-solving capabilities with a client-focused approach.
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Ability to communicate complex scientific concepts effectively to diverse audiences.
