Department: Global Health Economics & Outcomes Research (HEOR)
Job Family: Evidence Synthesis
Job Type: Full-Time
Location: Hyderabad, India
Reports To: Global HEOR Evidence Synthesis Team Lead
Position Summary
The Global HEOR Evidence Synthesis Manager plays a critical role in supporting Amgen’s global market access and health economics strategy through contributing statistical capabilities and methodological leadership for evidence synthesis methodologies (meta-analyses & ITCs). The Evidence Synthesis Manager will conduct different evidence pooling analyses ranging from meta-analyses, network meta-analyses to population-adjusted indirect treatment comparisons (MAICs and STCs) and health-economic analyses facilitating HTA and payer decision-making.
Educational Qualifications
A Bachelor’s, Master's or Doctoral-level degree in applied statistics, biostatistics, mathematics, operations research, engineering, health economics, pharmacy, and related quantitative fields
Required experience/ knowledge
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Years of relevant experience in evidence synthesis and statistical analyses in the pharmaceutical, biotech or consulting setting: +6 years for Master’s degree and +8 years for Bachelor’s degree.
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Hands-on experience in research design and statistical methods, including estimating survival, pooled treatment effects and other methods to estimate treatment effect
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Experience in conducting health economic analyses such as cost-effectiveness/cost-utility (e.g., markov, partitioned survival model), cost minimization, budget impact, and other techniques, as appropriate
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Proficiency with modeling and statistical tools such as Excel, WinBugs, OpenBugs, JAGS, R or Python.
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Familiarity with AI/ML techniques and Bayesian statistics is a plus.
Key Responsibilities
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Design and conduct advanced evidence synthesis and statistical analyses such as Pairwise Meta-Analysis, Surrogate outcome assessment, Survival analysis, External Control Arm (ECA) analysis, Indirect treatment comparison (ITCs), Network Meta-Analysis, Match adjusted indirect treatment analysis (MAIC), Simulated treatment comparison (STC) and Meta-regression
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Design and develop health economic models for products at all stages of development and launch, using cost-effectiveness/cost-utility (e.g., markov, partitioned survival model), cost minimization, budget impact, and other techniques, as appropriate.
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Ensure quality standards are adhered to in all analyses and new methodologies and techniques are adequately assessed and implemented.
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Plan and conduct statistical analyses of clinical trials, RWE and other relevant data sources and develop supporting technical documentation for statistical analyses and economic models.
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Monitor and integrate evolving HTA guidelines, payer requirements, and methodological advancements.
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Create QC checklists and establish robust QC processes across projects
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To proactively mentor and develop members of the team
Skills & Competencies
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Excellent English oral and written communication, with ability to tailor content to different stakeholders.
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Strong quantitative and analytical skills with attention to detail.
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Strong project management and time-management abilities.
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Innovative use of artificial intelligence to boost efficiency.
Organizational Behaviors
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Effective cross-functional collaboration and interpersonal skills.
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Proactive, independent, and detail-oriented approach to problem-solving.
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Comfortable working in a global team across time zones and cultures.
