Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Job Description
Role Overview
We’re not just looking for a lab executor here—this role sits at the intersection of process development, analytics, and scale-up.
As an Application Scientist – DSP, you will lead the design, development, and optimization of downstream purification processes for biologics in a single-use bioprocessing environment. You’ll play a key role in enabling robust, scalable, and compliant purification workflows while collaborating across upstream, analytics, quality, and manufacturing teams.
Key Responsibilities
1. Downstream Process Development & Optimization
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Design and optimize purification processes including:
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Chromatography (affinity, ion exchange, etc.)
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Filtration (TFF, depth filtration)
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Viral clearance strategies
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Perform lab-scale studies to evaluate process parameters for yield, purity, and robustness
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Implement and optimize single-use technologies in DSP workflows
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Integrate downstream processes with upstream and analytical workflows
2. Pharma Analytics & Characterization
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Execute and support analytical workflows including:
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qPCR (minimum 3–4 years hands-on)
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Sanger Sequencing
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Support impurity profiling and adventitious agent testing strategies
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Interpret analytical data to guide purification and process decisions
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Collaborate with analytical teams for method development and validation
3. Technology Transfer & Scale-Up
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Lead transfer of DSP processes from lab to pilot and commercial scale
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Develop and review:
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SOPs
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Batch records
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Technology transfer documents
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Troubleshoot scale-up challenges in single-use manufacturing environments
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Work closely with engineering and manufacturing teams
4. Data Analysis & Documentation
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Analyze experimental data for process performance and optimization opportunities
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Ensure compliance with Good Documentation Practices (GDP)
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Prepare:
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Technical reports
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Protocols
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Client/stakeholder presentations
5. Cross-Functional Collaboration
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Partner with:
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Upstream Processing
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Analytical Development
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Quality & Regulatory
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Provide technical expertise in DSP during:
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Project reviews
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Troubleshooting discussions
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Act as a subject matter expert (SME) for purification and analytics
6. Continuous Improvement & Innovation
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Track advancements in:
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Downstream processing technologies
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Single-use systems
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Process Analytical Technology (PAT)
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Drive improvements in process efficiency, scalability, and cost-effectiveness
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Contribute to innovation initiatives within BDC
Qualifications
Education
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Ph.D. / M.S. / B.S./Post Graduation in:
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Chemical Engineering
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Biotechnology
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Biochemistry
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Or related field
Experience
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8+ years in downstream process development in biopharma
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Strong expertise in:
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Chromatography
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TFF / filtration
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Viral clearance
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Hands-on lab experience with DSP equipment
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3–4+ years hands-on experience in:
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Experience in:
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Impurity testing
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Adventitious agent testing
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Exposure to:
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Pharma analytics
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Regulated environments (cGMP)
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Customer-facing or application roles (preferred)
Skills & Competencies
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Strong process development and troubleshooting capability
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Data-driven mindset with solid analytical skills
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Effective communication and presentation skills
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Ability to manage multiple projects and timelines
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Collaborative, team-oriented approach
Preferred / Desired Attributes
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Familiarity with:
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cGMP, ICH guidelines
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Regulatory expectations for biologics
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Knowledge of:
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PAT (Process Analytical Technology)
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Automation in DSP
