Dgm operations Jobs

Downstream Manufacturing (Classical Fermentation)
Symbiotec Pharmalab —Indore, Madhya Pradesh
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Flute Laminator machine Operator
DGM AUTOMATION INDIA PRIVATE LIMITED —Noida, Uttar Pradesh
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Downstream Manufacturing (Classical Fermentation)

Symbiotec Pharmalab -
Indore, Madhya Pradesh

Apply Now

Job details

2 days ago

Qualifications

Six Sigma Certification
Management
Chemical Engineering
SAP
Engineering
Master's degree
Quality assurance
Bachelor's degree
Manufacturing
Leadership
Lean Six Sigma Certification
Lean manufacturing
FDA regulations

Full job description

As part of the Symbiotec team, you'll get to work shoulder-to-shoulder with colleagues who are the best at what they do and will inspire you to be your best self

Downstream Manufacturing (Classical Fermentation)
DGM / AGM

Open

Department: Biopharma Downstream

Experience: 10 to 15 years
Qualification: Bachelor’s or Master’s degree in: Biochemical Engineering or Chemical Engineering

Published: 08 Jun 2026

Key Responsibilities

Job Description:
DGM / AGM – Downstream Manufacturing (Classical Fermentation)

Reporting To

Head –Biotech / Head- Down-Stream Process

________________________________________

Job Summary

The Employee will be responsible for leading downstream processing operations for classical fermentation-based biopharmaceutical products. The role involves overseeing separation, concentration, Column Chromatography, purification, and recovery activities while ensuring compliance with cGMP, quality standards, safety regulations, and production targets as per Pharmaceutical Industry norms. The position requires strong technical expertise in downstream bioprocessing and leadership capabilities to support commercial manufacturing operations efficiently and reliably.

________________________________________

Key Responsibilities:
Downstream Manufacturing Operations

Lead and manage downstream processing activities for Fermentation and Bio-Transformation-derived biopharmaceutical products.

Oversee operations including cell separation, filtration, centrifugation, extraction, concentration, chromatography drying, purification, and final product recovery.

Ensure adherence to approved batch manufacturing records (BMR), SOPs, and production schedules.

Monitor production performance to achieve yield, quality, and productivity targets.

Coordinate manufacturing activities to ensure smooth integration with upstream fermentation and final packaging operations.

Process Optimization & Technical Support

Identify and implement process improvements to enhance recovery efficiency, product purity, and operational productivity.

Troubleshoot downstream processing deviations, equipment issues, and process inefficiencies.

Support scale-up, process transfer, and commercialization of new products.

Participate in technology transfer activities from R&D to manufacturing.

Compliance & Quality Assurance

Ensure compliance with cGMP, regulatory guidelines, biosafety standards, and data integrity requirements.

Review and approve production documentation, logbooks, and batch records.

Lead investigations related to deviations, OOS/OOT events, CAPA, and change controls.

Support regulatory inspections, customer audits, and internal quality audits.

Equipment & Validation

Oversee operation and maintenance coordination for downstream equipment such as:

Centrifuges

Chromatography systems

Filtration units

Evaporators

Spray dryers / freeze dryers

Support qualification and validation activities including IQ/OQ/PQ, cleaning validation, and process validation.

Team Leadership

Manage and mentor production supervisors, engineers, operators, and technical staff.

Ensure proper manpower planning, training, and competency development.

Promote a culture of operational excellence, teamwork, and compliance.

Safety & EHS

Ensure safe handling of biological materials, chemicals, solvents, and process intermediates.

Maintain compliance with environmental, health, and safety (EHS) requirements.

Drive implementation of safe work practices and risk mitigation initiatives.

________________________________________

Required Qualifications:
Bachelor’s or Master’s degree in:
Biochemical Engineering

Chemical Engineering

________________________________________

Experience:
10–15+ years of experience in downstream manufacturing within biopharmaceutical, fermentation, or biotechnology focussed industries.

Strong expertise in downstream processing and purification technologies.

Experience in GMP-regulated manufacturing facilities.

Proven experience in handling commercial-scale operations and technical teams.

________________________________________

Technical Skills:
Strong understanding of downstream bioprocessing principles and unit operations.

Experience with purification technologies such as filtration, chromatography, precipitation, and drying systems.

Familiarity with process automation systems, CIP/SIP operations, and manufacturing control systems.

Knowledge of cGMP, FDA, EMA, WHO, and other regulatory standards.

Proficiency in batch documentation, validation protocols, and deviation investigations.

________________________________________

Behavioral Competencies:
Strong leadership and people management skills

Analytical and problem-solving capabilities

Effective communication and cross-functional collaboration

Attention to detail and quality focus

Ability to manage multiple priorities under tight timelines

________________________________________

Preferred:
Experience in manufacturing of antibiotics, enzymes, probiotics, or biologics.

Exposure to SAP, MES, SCADA, or automation platforms.

Lean Manufacturing / Six Sigma certification preferred.

________________________________________

Apply Now

Refine Your Search

Downstream Manufacturing (Classical Fermentation)

PSS

General Manager - Marketing

Executive- Maintenance

DGM / GM - Finance & Accounting

Customer Relationship Manager (CRM)

DGM - IBMS Sales

DGM / GM - Commercial Excellence

Research Scientist - Special Technologies

DGM- HR

DGM Solutions - IOA BFSI

DGM - Distribution & Sales

Intern - Business Development

DGM - Commissioning

DGM - Electrical

GM Sales – Govt. Business

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Flute Laminator machine Operator

Engagement Delivery Lead

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